|PENGARUH PEMBERIAN PROBIOTIK, PREBIOTIK, SINBIOTIK TERHADAP KEJADIAN DIARE PADA ANAK SEHAT USIA 1-5 TAHUN DI TAMAN PENITIPAN ANAK|
Virany Diana, drDepartemen/ SMF Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlangga/ RSUD Dr. Soetomo Surabaya (2009)
The Effects of Probiotic, Prebiotic, and Sinbiotic Administration on the Incidence and Duration of Diarrhea
in Healthy Child at Day Care Centre
Background: Day-care attendance is known to be a major risk factor for diarrhea in children. Probiotic, prebiotic, and synbiotic have been widely used as adjunctive therapy of gastrointestinal diseases. The possible health benefits of gut flora dominated by bifidobacteria have recognized for treatment and prevention of acute diarrhea in children. Three strategies to improve the colonisation of normal microflora. The question is whether probiotic, prebiotic, or synbiotic should be used to reach the best possible effect.
Objective: To investigate whether probiotic, prebiotic, or synbiotic could decrease the incidence and duration of diarrhea in healthy child in day care centre
Methods: This randomized double blind, placebo controlled clinical study was carried out in 12 day care centres, in similar socioeconomic areas in Surabaya, Gresik and Sidoarjo. Children aged 1-5 years, healthy condition, stay in day care centre were recruited if parents signed the informed consent form. Children with history of lactose intolerance, history of cow’s milk allergy, not in healthy condition 1 week prior the study, and consumed prebiotic, probiotic, synbiotic 2 weeks prior the study were exclude. Divided into 4 groups (probiotic, prebiotic, synbiotic, and control), intervention lasted 26 weeks. Parents and day care staff recorded daily any diarrhea episodes and duration. ANOVA and chi-square to compare differences between the groups.
Results: Total episodes of diarrhea in 6 months were decreased in probiotic, synbiotic, and prebiotic group compared with control group, but only prebiotic group significantly different. Duration each episode of diarrhea were decreased also in all intervention group, but not significantly different.
Conclusion: The use of Probiotic, prebiotic, and synbiotic decrease the incidence of diarrhea in healthy children.