PDF Cetak Email


Virany Diana, dr

Departemen/ SMF Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlangga/ RSUD Dr. Soetomo Surabaya (2009)



The Effects of  Probiotic, Prebiotic, and Sinbiotic Administration on the Incidence and Duration of Diarrhea

in Healthy Child at Day Care Centre


Background: Day-care attendance is known to be a major risk factor for diarrhea in children. Probiotic, prebiotic, and synbiotic have been widely used as adjunctive therapy of gastrointestinal diseases. The possible health benefits of gut flora dominated by bifidobacteria have recognized for treatment and prevention of acute diarrhea in children. Three strategies to improve the colonisation of normal microflora. The question is whether probiotic, prebiotic, or synbiotic should be used to reach the best possible effect.

Objective: To investigate whether probiotic, prebiotic, or synbiotic could decrease the incidence and duration of diarrhea in healthy child in day care centre

Methods: This randomized double blind, placebo controlled clinical study was carried out in 12 day care centres, in similar socioeconomic areas in Surabaya, Gresik and Sidoarjo. Children aged 1-5 years, healthy condition,  stay in day care centre were recruited if parents signed the informed consent form. Children with history of lactose intolerance, history of cow’s milk allergy, not in healthy condition 1 week prior the study, and consumed prebiotic, probiotic, synbiotic 2 weeks prior the study were exclude. Divided into 4 groups (probiotic, prebiotic, synbiotic, and control),  intervention lasted 26  weeks. Parents and day care staff recorded daily any diarrhea episodes and duration. ANOVA and chi-square to compare differences between the groups.

Results: Total episodes of diarrhea in 6 months were decreased in probiotic, synbiotic, and prebiotic group compared with control group, but only prebiotic group significantly different. Duration each episode of diarrhea were decreased also in all intervention group, but not significantly different.

Conclusion: The use of Probiotic, prebiotic, and synbiotic decrease the incidence of diarrhea in healthy children.


Your are currently browsing this site with Internet Explorer 6 (IE6).

Your current web browser must be updated to version 7 of Internet Explorer (IE7) to take advantage of all of template's capabilities.

Why should I upgrade to Internet Explorer 7? Microsoft has redesigned Internet Explorer from the ground up, with better security, new capabilities, and a whole new interface. Many changes resulted from the feedback of millions of users who tested prerelease versions of the new browser. The most compelling reason to upgrade is the improved security. The Internet of today is not the Internet of five years ago. There are dangers that simply didn't exist back in 2001, when Internet Explorer 6 was released to the world. Internet Explorer 7 makes surfing the web fundamentally safer by offering greater protection against viruses, spyware, and other online risks.

Get free downloads for Internet Explorer 7, including recommended updates as they become available. To download Internet Explorer 7 in the language of your choice, please visit the Internet Explorer 7 worldwide page.